Drugs that have restrictions other than prior authorization, quantity boundaries, and action therapy linked with Every single prescription.

nalbuphine decreases effects of fentanyl by pharmacodynamic antagonism. Stay clear of or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may lessen fentanyl's analgesic effect And maybe precipitate withdrawal symptoms.

lonapegsomatropin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Cases of serotonin syndrome, a potentially life-threatening condition, reported with concomitant use of serotonergic drugs; this might come about within the advisable dosage vary; the onset of symptoms generally happen within numerous hrs to a couple of days of concomitant use, but may well come about later on than that; discontinue therapy right away if serotonin syndrome is suspected

Opioids can cause slumber-related respiration disorders which include central snooze apnea (CSA) and sleep-related hypoxemia; opioid use boosts risk of CSA within a dose-dependent fashion; in patients who current with CSA, consider decreasing opioid dosage using ideal methods for opioid taper

Set the tablet in your mouth, either less than your tongue, or between your cheek and gum dependant upon the type of tablet you might have.

nevirapine will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some decrease in fentanyl plasma concentrations, lack of efficacy or, maybe, growth of the withdrawal syndrome inside a patient that has made physical dependence to fentanyl.

Watch Intently (two)fentanyl will boost the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Serious - Use Alternative (one)fosphenytoin will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers could lead to a decrease in fentanyl plasma concentrations, not enough efficacy or, quite possibly, enhancement of a withdrawal syndrome inside a affected individual that has developed Bodily dependence fentanyl treatment program to fentanyl.

acetazolamide will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.

If coadministration of CYP3A4 inhibitors with fentanyl is important, check patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose adjustments until stable drug effects are realized.

nirmatrelvir/ritonavir will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Modify Therapy/Check Closely. Observe for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes until finally stable drug effects are achieved.

tranylcypromine increases toxicity of fentanyl by Other (see remark). Contraindicated. Remark: Steer clear of fentanyl in patients who involve concomitant administration MAOIs, or within fourteen times of stopping an MAOI. Serious and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.